What is Tramadol?
Tramadol is the Trade name for the moderate to severe painkilling opiod analgesic drug cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride.
Tramadol was Developed in the late 70's by the german manufacturers Grünenthal GmbH who marketed the drug under the more common trade name of Tramal. They also cross licensed it to other pharmaceutical companies who market it under various other trade names such as, Ultram and ULTRAM® ER.
Tramadol is closely related to the pharmaceutical drug tapentadol, in terms of chemical composition.
Tramadol is not a nonsteroidal antiinflammatory drug (NSAID) and does not have the increased risk of stomach ulceration and internal bleeding that can occur with NSAIDs.
Tramadol is one of the most prescribed painkillers in the Western world. Please ensure you Buy Tramadol from reliable online pharmacies.
Tramadol was Developed in the late 70's by the german manufacturers Grünenthal GmbH who marketed the drug under the more common trade name of Tramal. They also cross licensed it to other pharmaceutical companies who market it under various other trade names such as, Ultram and ULTRAM® ER.
Tramadol is closely related to the pharmaceutical drug tapentadol, in terms of chemical composition.
Tramadol is not a nonsteroidal antiinflammatory drug (NSAID) and does not have the increased risk of stomach ulceration and internal bleeding that can occur with NSAIDs.
Tramadol is one of the most prescribed painkillers in the Western world. Please ensure you Buy Tramadol from reliable online pharmacies.
Wednesday, 9 December 2009
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What is Tramadol used for?
Tramadol is used to relieve moderate to severe pain.
Such As :-
To treat pain caused by surgery.
Cancer pain.
Joint Pain.
A popular arthritis pain reliever.
Chronic Low Back Pain.
Chronic neuropathic pain.
The pain of diabetic neuropathy.
Therapy for musculoskeletal pain.
The treatment of fibromyalgia pain.
Tramadol can be used as an effective treatment for all these plus many other types of pain.
Such As :-
To treat pain caused by surgery.
Cancer pain.
Joint Pain.
A popular arthritis pain reliever.
Chronic Low Back Pain.
Chronic neuropathic pain.
The pain of diabetic neuropathy.
Therapy for musculoskeletal pain.
The treatment of fibromyalgia pain.
Tramadol can be used as an effective treatment for all these plus many other types of pain.
How is Tramadol Administered?
Tramadol Can be administered in the following ways.
By soluble Tablet, ensure tablet is fully dissolved before taking.
By orodispersible (melt in the mouth) Tablets, these will dissolve quickly within the mouth or may be dissolved within a glass of water, But must be drunk immediately.
There are modified released forms giving slow release over a long period of time.
Adults (17 Years Of Age And Over): For patients with moderate to moderately severe chronic pain not requiring rapid onset of analgesic effect, the tolerability of Tramadol hydrochloride tablets can be improved by initiating therapy with a titration regimen: The total daily dose may be increased by 50 mg as tolerated every 3 days to reach 200 mg/day (50 mg q.i.d.). After titration, Tramadol hydrochloride tablets 50 to 100 mg can be administered as needed for pain relief every 4 to 6 hours not to exceed 400 mg/day.
For the subset of patients for whom rapid onset of analgesic effect is required and for whom the benefits outweigh the risk of discontinuation due to adverse events associated with higher initial doses, Tramadol hydrochloride tablets 50 mg to 100 mg can be administered as needed for pain relief every four to six hours, not to exceed 400 mg per day.
Individualization Of Dose: Good pain management practice dictates that the dose be individualized according to patient need using the lowest beneficial dose. Studies with Tramadol in adults have shown that starting at the lowest possible dose and titrating upward will result in fewer discontinuations and increased tolerability.
• In all patients with creatinine clearance less than 30 mL/min, it is recommended that the
dosing interval of Tramadol hydrochloride be increased to 12 hours, with a maximum daily dose of 200 mg. Since only 7% of an administered dose is removed by hemodialysis, dialysis patients can receive their regular dose on the day of dialysis.
• The recommended dose for adult patients with cirrhosis is 50 mg every 12 hours.
• In general, dose selection for an elderly patient over 65 years old should be cautious, usually
starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function and of concomitant disease or other drug therapy. For elderly patients over 75 years old, total dose should not exceed 300 mg/day.
Tramadol can also be administered intravenously, by trained medical personel only. Tramdol must be dilluted before administrating intravenously.
Only take tramadol as prescribed by your GP, Doctor.
By soluble Tablet, ensure tablet is fully dissolved before taking.
By orodispersible (melt in the mouth) Tablets, these will dissolve quickly within the mouth or may be dissolved within a glass of water, But must be drunk immediately.
There are modified released forms giving slow release over a long period of time.
Adults (17 Years Of Age And Over): For patients with moderate to moderately severe chronic pain not requiring rapid onset of analgesic effect, the tolerability of Tramadol hydrochloride tablets can be improved by initiating therapy with a titration regimen: The total daily dose may be increased by 50 mg as tolerated every 3 days to reach 200 mg/day (50 mg q.i.d.). After titration, Tramadol hydrochloride tablets 50 to 100 mg can be administered as needed for pain relief every 4 to 6 hours not to exceed 400 mg/day.
For the subset of patients for whom rapid onset of analgesic effect is required and for whom the benefits outweigh the risk of discontinuation due to adverse events associated with higher initial doses, Tramadol hydrochloride tablets 50 mg to 100 mg can be administered as needed for pain relief every four to six hours, not to exceed 400 mg per day.
Individualization Of Dose: Good pain management practice dictates that the dose be individualized according to patient need using the lowest beneficial dose. Studies with Tramadol in adults have shown that starting at the lowest possible dose and titrating upward will result in fewer discontinuations and increased tolerability.
• In all patients with creatinine clearance less than 30 mL/min, it is recommended that the
dosing interval of Tramadol hydrochloride be increased to 12 hours, with a maximum daily dose of 200 mg. Since only 7% of an administered dose is removed by hemodialysis, dialysis patients can receive their regular dose on the day of dialysis.
• The recommended dose for adult patients with cirrhosis is 50 mg every 12 hours.
• In general, dose selection for an elderly patient over 65 years old should be cautious, usually
starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function and of concomitant disease or other drug therapy. For elderly patients over 75 years old, total dose should not exceed 300 mg/day.
Tramadol can also be administered intravenously, by trained medical personel only. Tramdol must be dilluted before administrating intravenously.
Only take tramadol as prescribed by your GP, Doctor.
How Does Tramadol Work?
Tramadol capsules, soluble tablets and injection all contain the active ingredient tramadol hydrochloride, which is a type of medicine called an opioid painkiller.
Opioid painkillers work by Copying the action of naturally occurring pain-reducing chemicals called endorphins.
Endorphins are found in the brain and spinal cord and reduce pain by combining with opioid receptors.
Tramadol Copies the action of our natural endorphins by combining with the opioid receptors in the brain and spinal cord So the transmission of pain signals sent by the nerves to the brain is Restricted. Resulting in a lowering of the pain experienced.
Therefore, even though the cause of the pain may remain, less pain is actually felt.
Tramadol also works by multiplying the activity of neurotransmitters in the brain and spinal cord.
Neurotransmitters are chemical compounds that act as chemical messengers between the nerve cells.
Tramadol heighten the effect of the neurotransmitters serotonin and noradrenaline, aiding the relief of pain.
Tramadol is a moderately strong painkiller used in the management of moderate to severe pain.
It is given by injection when administration by mouth is not possible, I.e after surgery.
The injection is given intravenously into a muscle or vein, or via a drip into a vein
Tramadol capsules and soluble tablets are taken by mouth up to six times a day, depending on the severity of the pain.
Tramadol soluble tablets should be dissolved in at least 50ml of water before taking. These forms of tramadol should not be taken more often than every four hours and you should not exceed the dose prescribed by your doctor.
For more prolonged pain relief, modified release forms of tramadol that can be taken once or twice a day are available.
Opioid painkillers work by Copying the action of naturally occurring pain-reducing chemicals called endorphins.
Endorphins are found in the brain and spinal cord and reduce pain by combining with opioid receptors.
Tramadol Copies the action of our natural endorphins by combining with the opioid receptors in the brain and spinal cord So the transmission of pain signals sent by the nerves to the brain is Restricted. Resulting in a lowering of the pain experienced.
Therefore, even though the cause of the pain may remain, less pain is actually felt.
Tramadol also works by multiplying the activity of neurotransmitters in the brain and spinal cord.
Neurotransmitters are chemical compounds that act as chemical messengers between the nerve cells.
Tramadol heighten the effect of the neurotransmitters serotonin and noradrenaline, aiding the relief of pain.
Tramadol is a moderately strong painkiller used in the management of moderate to severe pain.
It is given by injection when administration by mouth is not possible, I.e after surgery.
The injection is given intravenously into a muscle or vein, or via a drip into a vein
Tramadol capsules and soluble tablets are taken by mouth up to six times a day, depending on the severity of the pain.
Tramadol soluble tablets should be dissolved in at least 50ml of water before taking. These forms of tramadol should not be taken more often than every four hours and you should not exceed the dose prescribed by your doctor.
For more prolonged pain relief, modified release forms of tramadol that can be taken once or twice a day are available.
What are The Side effects of Tramadol?
As with all drugs tramadol does have a few side effects and should not be taken in combinations withother medication.
Please remember as a race human beings are more prone to complain than to say thank you. as a result of this phenomenum you are more likely to come accross some horror stories about a certain drug than you will come accross testimonials as to how effective that particular drug is.
having said this the reported side effects of tramadol are.
Feeling or being sick
Drink plenty of liquid. Stick to simple foods such as dry toast. If vomiting continues to be a problem speak to your doctor.
Constipation
Try to eat a well balanced diet containing plenty of fibre and drink 6-8 glasses of water each day. If constipation continues to be a problem speak to your pharmacist or doctor.
Diarrhoea
Drink plenty of water to replace lost fluids. If diarrhoea continues to be a problem speak to your pharmacist or doctor.
Dry mouth
Try chewing sugar-free gum, sucking pieces of ice or sugar-free sweets. If this becomes troublesome speak to your pharmacist or doctor.
Headache, dizziness, a fast or fluttering heartbeat, seeing or hearing things that aren't real, mood changes, confusion, pins and needles, sexual problems or skin rashes, difficulty urinating (passing water)
Speak with your doctor.
Tramadol is generally well tolerated, and side effects are usually transient. Commonly reported side effects include nausea, constipation, dizziness, headache, drowsiness, and vomiting. Less commonly reported side effects include itching, sweating, dry mouth, diarrhea, rash, visual disturbances, and vertigo. Some patients who received tramadol have reported seizures. Abrupt withdrawal of tramadol may result in anxiety, sweating, insomnia, rigors, pain, nausea, diarrhea, tremors, and hallucinations.
While taking Tramadol do not drink alcohol, which may dangerously affect breathing or cause liver problems. Take care when driving, operating machinery, or performing other hazardous activities. This drug can be habit-forming. Do not increase the size or frequency of your dose unless so advised by your doctor - and call your doctor if you find that you want to take more Tramadol or notice unusual changes in your mood or behaviour. Do not suddenly stop taking the medication or you are likely to experience unpleasant withdrawal symptoms.
Please remember as a race human beings are more prone to complain than to say thank you. as a result of this phenomenum you are more likely to come accross some horror stories about a certain drug than you will come accross testimonials as to how effective that particular drug is.
having said this the reported side effects of tramadol are.
Feeling or being sick
Drink plenty of liquid. Stick to simple foods such as dry toast. If vomiting continues to be a problem speak to your doctor.
Constipation
Try to eat a well balanced diet containing plenty of fibre and drink 6-8 glasses of water each day. If constipation continues to be a problem speak to your pharmacist or doctor.
Diarrhoea
Drink plenty of water to replace lost fluids. If diarrhoea continues to be a problem speak to your pharmacist or doctor.
Dry mouth
Try chewing sugar-free gum, sucking pieces of ice or sugar-free sweets. If this becomes troublesome speak to your pharmacist or doctor.
Headache, dizziness, a fast or fluttering heartbeat, seeing or hearing things that aren't real, mood changes, confusion, pins and needles, sexual problems or skin rashes, difficulty urinating (passing water)
Speak with your doctor.
Tramadol is generally well tolerated, and side effects are usually transient. Commonly reported side effects include nausea, constipation, dizziness, headache, drowsiness, and vomiting. Less commonly reported side effects include itching, sweating, dry mouth, diarrhea, rash, visual disturbances, and vertigo. Some patients who received tramadol have reported seizures. Abrupt withdrawal of tramadol may result in anxiety, sweating, insomnia, rigors, pain, nausea, diarrhea, tremors, and hallucinations.
While taking Tramadol do not drink alcohol, which may dangerously affect breathing or cause liver problems. Take care when driving, operating machinery, or performing other hazardous activities. This drug can be habit-forming. Do not increase the size or frequency of your dose unless so advised by your doctor - and call your doctor if you find that you want to take more Tramadol or notice unusual changes in your mood or behaviour. Do not suddenly stop taking the medication or you are likely to experience unpleasant withdrawal symptoms.
What is tramadol made from? how is tramadol made?
Tramadol is a member of the opiate family and is related to the more well known of this family morphine.
The Systematic (IUPAC) name for tramadol is
(±)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride.
The chemical formula for tramadol is.
C16H25NO2.
The Systematic (IUPAC) name for tramadol is
(±)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride.
The chemical formula for tramadol is.
C16H25NO2.
Tramadol Aliases
Tramadol has many different worldwide names
some of which include.
Acugesic (in Malaysia and Singapore)
Adolan Adolonta (in Spain)
Anadol (in Portugal)
Boldol (in Bosnia and Herzegovina)
Calmador (in Argentina)
Campex (in Pakistan)
Contramal (in India and Italy)
Crispin Dolcet (in the Philippines)
Dolol (in Denmark)
Dolzam (in Belgium)
Dromadol (in UK)
Exopen (in South Korea)
Ixprim (in France)
Lumidol (in Croatia)
Mandolgin (in Denmark)
Mandolgine
Mosepan
Nobligan
Osteodol (Fem India)
Poltram
Ralivia (In Canada)
Sintradon
Siverol (in the Philippines)
Tamool
Tandol (in South Korea)
Tedool
Tiparol
Toplagic
Tradol
Tradolan
Tradonal (in the Philippines)
Tralgit
Tralodie (in Italy)
Tramacet (combined with paracetamol)
Tramacip
Tramadex (in Israel)
Tramadin
Tramadol
Tramadolor
Tramahexal
Tramajack
Tramake Insts (in United Kingdom)
Trama-Klosidol
Tramal (in the Netherlands, Finland, Slovenia, Chile, Romania, Australia, New Zealand and Switzerland)
Tramalgic (in Hungary)
Tramal Gotas (in Ecuador)
Tramauydin
Tramazac (in India)
Tramedo
Tramoda (in Thailand)
Tramundal (various Austrian solid and liquid forms manufacturd by Mundipharma Ges. m.b.H, in Vienna and available elsewhere in Central Europe as well)
Tridol (in South Korea)
Tridural (in Canada)
Trodon (in Serbia)
Ultracet (combined with paracetamol)
Ultradol
Ultram and Ultram ER (in the US)
Ultramed (combined with paracetamol) in India
Veldrol (in Mexico)
Zafin (combined with paracetamol, in Chile)
Zaldiar (combined with paracetamol, in Spain, Russia, Chile) Zaledor (combined with paracetamol, in Chile)
Zamadol (in UK)
Zamudol
Zodol (in Ecuador)
Zydol (in the UK and Australia)
Zytram
Zytrim (in Spain)
some of which include.
Acugesic (in Malaysia and Singapore)
Adolan Adolonta (in Spain)
Anadol (in Portugal)
Boldol (in Bosnia and Herzegovina)
Calmador (in Argentina)
Campex (in Pakistan)
Contramal (in India and Italy)
Crispin Dolcet (in the Philippines)
Dolol (in Denmark)
Dolzam (in Belgium)
Dromadol (in UK)
Exopen (in South Korea)
Ixprim (in France)
Lumidol (in Croatia)
Mandolgin (in Denmark)
Mandolgine
Mosepan
Nobligan
Osteodol (Fem India)
Poltram
Ralivia (In Canada)
Sintradon
Siverol (in the Philippines)
Tamool
Tandol (in South Korea)
Tedool
Tiparol
Toplagic
Tradol
Tradolan
Tradonal (in the Philippines)
Tralgit
Tralodie (in Italy)
Tramacet (combined with paracetamol)
Tramacip
Tramadex (in Israel)
Tramadin
Tramadol
Tramadolor
Tramahexal
Tramajack
Tramake Insts (in United Kingdom)
Trama-Klosidol
Tramal (in the Netherlands, Finland, Slovenia, Chile, Romania, Australia, New Zealand and Switzerland)
Tramalgic (in Hungary)
Tramal Gotas (in Ecuador)
Tramauydin
Tramazac (in India)
Tramedo
Tramoda (in Thailand)
Tramundal (various Austrian solid and liquid forms manufacturd by Mundipharma Ges. m.b.H, in Vienna and available elsewhere in Central Europe as well)
Tridol (in South Korea)
Tridural (in Canada)
Trodon (in Serbia)
Ultracet (combined with paracetamol)
Ultradol
Ultram and Ultram ER (in the US)
Ultramed (combined with paracetamol) in India
Veldrol (in Mexico)
Zafin (combined with paracetamol, in Chile)
Zaldiar (combined with paracetamol, in Spain, Russia, Chile) Zaledor (combined with paracetamol, in Chile)
Zamadol (in UK)
Zamudol
Zodol (in Ecuador)
Zydol (in the UK and Australia)
Zytram
Zytrim (in Spain)
What alternatives are There to Tramadol?
As Tramadol is a simple opiod painkiller there are many alternatives that can be used effectively as a painkiller.
these include.
Morphine, hydromorphone, methadone, levorphanol, fentanyl, and important quantities of oxycodone are used to relieve more severe pain.
codeine, propoxyphene, and pentazocine
these include.
Morphine, hydromorphone, methadone, levorphanol, fentanyl, and important quantities of oxycodone are used to relieve more severe pain.
codeine, propoxyphene, and pentazocine
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